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It reflects normal physiological adaptation, Pratley says

Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs), a class of glucose-lowering drugs, have demonstrated a wide range of pleiotropic effects that extend beyond glycaemic control

The neuroinflammatory processes observed in obesity are similar to those seen in neurodegenerative diseases, with microglial activation, reactive astrogliosis, and insulin resistance playing key roles

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Influencing adipokines: Adipose tissue, or body fat, produces signaling molecules known as adipokines, some of which promote inflammation