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doi:10.1038/nature08636

Numerous in vitro and in vivo studies have demonstrated the ability of shiitake mushrooms to prevent or mitigate various diseases, enhance immune function, improve overall health, and potentially extend life expectancy

In contrast, continuous immoderate food consumption can override the usual homeostatic mechanisms and cause the development of obesity

Nat Immunol (2010) 11(5):4118.10.1038/ni.1857 121 DengJLuPDZhangYScheunerDKaufmanRJSonenbergNet alTranslational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

It plays an important role in protecting cells from oxidative stress caused by environmental exposure, stress, and everyday lifestyle factors