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The answer lies in the following: Ozempic is more stable than endogenous GLP-1: Where the naturally produced GLP-1 breaks down within a few minutes by bodily enzymes, Ozempic can last for a week (thats why it is injected once weekly) due to modifications in its molecule

10.1155/2022/7864976 162 ZhangN.QiuQ.ChenY.SunZ.LuG.WangL.et al (2023a)

Plan exclusions and prior authorization requirements create significant coverage barriers for many UnitedHealthcare members

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Effects of sodium glucose cotransporter 2 inhibitors on risk of dyslipidemia among patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials