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Although clinically effective, they are associated with significant metabolic side effects, including increased insulin resistance, impaired function of pancreatic -cells, and, finally, weight gain

These effects are real but work at a systemic level rather than targeting specific injury sites

Along with preclinical data indicating that long-acting GIPR agonists act in the brain to decrease body weight and food intake via GIPR signalling in inhibitory -aminobutyric acid-producing (GABAergic) neurons 5,6,7 , and by mitigating the emetic effects of GLP-1R agonism 8,9 , GIPRGLP-1R co-agonism has been established as a highly effective strategy for the management of obesity, type 2 diabetes and MASH

This is because research work on this has not been done

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