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They projected based on the known weight loss effects (15% average weight loss) of this therapy that its use could result in 43 million fewer people with obesity, and prevent up to 1.5 million heart attacks, strokes and other adverse cardiovascular events over 10 years

If a study is trying to measure GH pulse effects, timing should be standardized across observations rather than improvised from internet dosage charts

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Key takeaways TRIUMPH-4 is the first successful Phase 3 readout for retatrutide, reporting 28.7% mean body-weight reduction at 68 weeks on the 12 mg weekly dose (26.4% on 9 mg, 2.1% on placebo)