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Safety Compared to hGH: Because it doesnt significantly raise IGF-1 or activate growth pathways, it avoids common hGH risks like unhealthy organ growth, insulin resistance, pre-diabetes, and swelling in joints (edema)

Psychiatry 10 , 329332 (2005)

Dermatology Partners Grapevine and Keller, Recent research on GLP-1s and inflammatory skin health highlights how many of these medications also modulate immune function, reduce C-reactive protein (CRP), and downregulate inflammatory pathways

Article: Lipoprotein(a): Berberine has been shown to decrease cholesterol levels as well as decrease Lp(a) levels .[ref][ref](Be sure to read the full article on Lp(a) if you have either of the first two variants.) Cautions with berberine: Berberine uses CYP3A4 and CYP2D6 enzymes for metabolism