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doi: 10.3389/fnut.2022.1082097 Received 27 October 2022 Accepted 21 December 2022 Published 10 January 2023 Volume 9 - 2022 Edited by Sandro Massao Hirabara, Universidade Cruzeiro Do Sul, Brazil Reviewed by Elisabetta Camajani, Sapienza University of Rome, Italy

In obesity management, conventional interventions, such as lifestyle modification and traditional pharmacotherapy, demonstrate limited efficacy in patients with moderate to severe obesity, and sustained weight loss is difficult to achieve