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Tirzepatide (sold as Mounjaro and Zepbound) is FDA approved and available now, while Retatrutide remains in Phase 3 trials with expected approval sometime between 2026 and 2027

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As GIP and GLP-1 exert their actions through structurally similar G protein coupled receptors, the differential mechanisms underlying preserved GLP-1, but not GIP, insulin stimulatory responses in diabetic cells have remained enigmatic

Images Image 1: Courtesy of Steven Daveluy MD, FAAD Image 2: Courtesy of Lindsey Bordone, MD, FAAD Image 3: Property of American Academy of Dermatology References Lal K, Herringshaw E