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The GLP1RA exenatide ameliorates drug-induced ROS production in neurons by increasing expression of the base excision repair protein, APE1, and activating this geno-protective pathway in vitro and in vivo [102]

Central to this is the role of probiotics in balancing gut bacteria, which in turn affects digestion, immunity, and nutrient absorption

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While their glycemic, weight-lowering, and cardiovascular benefits are well established through randomized trials and meta-analyses, concerns remain regarding their safety and tolerability across diverse populations and clinical settings