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10.1001/jamanetworkopen.2024.34180 172 LeeJ.WestD.PellegriniC.WeiJ.WilcoxS.Neils-StrunjasJ.et al (2025)

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Notably, CYP19A1 (encoding aromatase enzyme responsible for androgen to estrogen conversion) was significantly upregulated in both lipedema adipose tissue and the SVF

The 'no DAC' modification is critical: the original CJC-1295 formulation included Drug Affinity Complex, which extended half-life to two weeks but created sustained rather than pulsatile GH release

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