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It most commonly occurs during the titration phase (the period during which your doctor gradually increases your dose to reach the maintenance level)

Unlike sarcopenia, which requires both loss of muscle quantity and reduced function, lean mass reduction is a body-composition outcome most often assessed using dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA) [2, 20]

This is especially important during the higher dose phases

Functional brain imaging techniques, such as functional magnetic resonance imaging (fMRI) and fluoro-deoxy-glucose positron emission tomography (FDG-PET), have shown that the orbitofrontal cortex (OFC) is activated when individuals consume food until they feel full

Understanding when to talk to doctors about B12 dosage is important for safe treatment of neuropathy