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In general, cancer disease has a better prognosis and response to treatment when neoplastic cells display higher degrees of differentiation

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Genetic inhibition or the targeted inhibitor of IGF-2, lincitinib, markedly enhances the response to immune checkpoint blockade, suggesting the potential of IGF-2 as a biomarker and therapeutic target in immunotherapy (141)

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25 Gulcan, E., Toker, S., Hatipolu, H., Gulcan, A