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Am J Physiol Regul Integr Comp Physiol 283 : R905R910

The large-scale clinical trials (STEP for semaglutide, SURMOUNT for tirzepatide) were conducted with the FDA-approved brand-name formulations

Animals were monitored at least twice daily throughout the studies, including pre- and post-dose observations on dosing days

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[1] [2] In the pancreas (-cells of the islets of Langerhans), proglucagon is cleaved by prohormone convertase (PC) 2 producing glicentin-related pancreatic peptide (GRPP), glucagon, intervening peptide-1 (IP-1) and major proglucagon fragment (MPGF)