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In line with this, it has been demonstrated that a deficiency in this transporter in transgenic mice overexpressing human APP can exacerbate neurovascular dysfunction in AD by generating a series of parallel pathogenic mechanisms in the cerebral microcirculation, namely, a significant reduction in the expression of tight junctions, capillary degeneration, neurovascular uncoupling, BBB breakdown, decreased brain perfusion and impaired A clearance (Winkler et al., 2015)

PLoS One 11 (9), e0162717

#10 Medical Conditions Certain medical conditions such as diabetes, liver diseases, chronic kidney disease, and neurodegenerative disorders can hinder glutathione synthesis or utilization

Practical Foods and Meal Ideas Adopting a nutrient-rich diet begins in the kitchen

Jeyakumar Y, Richardson L, Sarma S, Retnakaran R, Kramer CK