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The breakdown in immune tolerance is a hallmark of SLE development (315), as well as many other autoimmune disorders (316)
Free radicals are unstable molecules formed during intense exercise, PED use, toxin exposure, or even just from breathing
ROS are closely related to myocardial necroptosis
For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]
naloxone reverses mu-opioid effects and emergency medical help should be sought immediately for any accidental human exposure
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