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This systemic mechanism is part of why TB-500 is sometimes considered for injuries that involve more diffuse tissue involvement or chronic, widespread inflammation rather than a single discrete injury site

Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C,

Classification and therapeutic mechanisms of NADs NADs can be broadly divided into three categories based on their mechanisms of action

It should be noted that in certain cell types or cell lines, inhibition of GPX4 fails to induce ferroptosis, suggesting the existence of alternative mechanisms

Cancer Cell 10:375-388, 2006