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LOWCancer LOWAllergies & Immunotoxicity LOWDevelopmental and Reproductive Toxicity LOWUse Restrictions Ingredient concerns CONCERNS DATA SOURCES Products with this Ingredient Organ system toxicity (non-reproductive) Persistence and bioaccumulation Ecotoxicology Environment Canada Understanding scores Cosmetics and personal care products are not required to be tested for safety before being allowed on the market

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Crosignani PG, Colombo M, Vegetti W, Somigliana E, Gessati A, Ragni G

"IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-B signaling pathways to promote wound healing." Biomedicine & Pharmacotherapy