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Side effects may include: a feeling of warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angio-edema, cyanosis, pulmonary edema, and hemorrhage into the gastrointestinal tract

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This has been demonstrated in models of Parkinsons disease, Alzheimers disease, and ALS, where NAD+ enhancement improved mitochondrial function, reduced neuroinflammation, and enhanced cognitive and synaptic functions