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Morgante CV, Rodrigues RA, Marbach PA, Borgonovi CM, Moura DS, Silva-Filho MC
[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Zhang LH, Tang M, Tao X, Shao Q, Thomas V, Shimizu S, Kasano M, Ishikawa Y, Inukai T, Nomura DK: Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis
This decline directly impacts your skin's ability to defend against oxidative damage and maintain its natural radiance
Deficiency can lead to megaloblastic anaemia and neurological complications
Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response
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