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[18] These analyses were exploratory and not primary endpoints of the trials

Fatigue affects 5-11% of patients and typically results from substantial caloric restriction due to appetite suppression, gastrointestinal side effects like nausea and vomiting, dehydration from reduced oral intake, or rapid metabolic changes during weight loss

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Hypersensitivity to the active substance or to any of the excipients

As the drugs gain more health indications, the argument for mandatory insurance coverage strengthens, forcing manufacturers to adjust their pricing strategy to align with population-level affordability and large volume sales