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January 13, 2022

When GLP-1 receptor signaling remains constant, your brain's hunger centers can develop tolerance, gradually reducing the drug's appetite-dampening effect

In a deal worth up to $285 million initially for the lead program, Novo Nordisk will gain access to Ascendis TransCon technology platform in an effort to find novel GLP-1 candidates with reduced dosing frequency

After binding of the GST fusion protein to the glutathione sepharose matrix, the mixture is incubated with whole-cell homogenate or a purified protein

However, most patients experience improvement within 24 weeks as their bodies adapt to the medication