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Despite the existence of numerous other obesity-related complications (including, but not limited to, polycystic ovary syndrome, infertility, asthma and COVID), the model only considers the most clinically and economically relevant complications: prediabetes, T2DM, CVD (angina, stroke and MI), MAFLD, OSA, knee osteoarthritis and bariatric surgery
In the 24-week LIVE trial in people with stable chronic HF (with or without diabetes), liraglutide did not meaningfully improve LV EF or other variables including quality of life (Jorsal et al., 2017)
Dipeptidyl Peptidase IV Inhibition Downregulates Na+ - H+ Exchanger NHE3 in Rat Renal Proximal Tubule