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Novaes R, Freire-de-Lima CG, de Albuquerque RC, Affonso-Mitidieri OR, Espindola O, Lima MA, de Andrada Serpa MJ, Echevarria-Lima J

Each step up gives the GLP-1 and GIP receptors time to adjust to increased stimulation

Most protocols start at a low dose and increase at regular intervals (typically every 4 weeks)

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"Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease." International Clinical Psychopharmacology