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These neurons project to multiple sites, including the lateral parabrachial nucleus (LPBN), ventrolateral periaqueductal grey matter (vlPAG), nucleus tractus solitarius and dorsal motor nucleus of the vagus (DMV) (Figure 2) (Garfield et al., 2015)

Novo Nordisk has also published phase 3 data showing an average weight loss of 11.8% using cagrilintide, a long-acting amylin analogue, alongside lifestyle interventions over a period of 68 weeks compared to 2.3% with placebo 7

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