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As a classic satiation signal, however, the literature illustrates a mixed picture of GIP involvement with an at best weak anorectic response profile being reported for GIP receptor (GIPR) signaling

We provide recommendations for use of specific obesity pharmacotherapies with proven benefit in specific subpopulations atherosclerotic cardiovascular disease, heart failure with preserved ejection fraction, metabolic dysfunctionassociated steatohepatitis, prediabetes, type 2 diabetes, obstructive sleep apnea, osteoarthritis and for those with certain specific monogenic causes of obesity

Gel packs or refrigerants to maintain the 36F to 46F range