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Side Effects Semaglutide: Common Side Effects: Nausea Vomiting Diarrhoea Constipation Abdominal pain Less Common Side Effects: Headache Fatigue Dizziness Hypoglycaemia (especially in individuals with type 2 diabetes) Pancreatitis (rare but serious) Tirzepatide: Common Side Effects: Nausea Vomiting Diarrhea Constipation Abdominal pain Less Common Side Effects: Decreased appetite Dyspepsia (indigestion) Injection site reactions Hypoglycemia (more common when combined with insulin or sulfonylureas) Pancreatitis (rare but serious) Administration Semaglutide: Administered via injection

Acknowledgements We sincerely thank the researchers who per formed the relevant GWAS and made the summary statistics publicly available