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They may not feel confident in current dosing guidelines, in managing side effects, or in identifying which patients will benefit most from GLP-1s compared with other options

Cost and Availability Tirzepatide: Often newer and can be more expensive

The only antidepressants that pose a risk of rare interaction are classified as MAOIs, which are older and less commonly prescribed

Moreover, chronic use of pain medications can lead to dependency or side effects, and surgery doesnt guarantee lasting results if the underlying weight issues persist

All reactions were conducted at pH 6.5 in 100 mM phosphate buffer at 30 C to ensure optimal enzymatic activity