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Antigens, which are proteins or other compounds that elicit an immunological response, can be encapsulated or adsorbed by CH-NPs (Goharshadi et al., 2022)

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The rationale is receptor pathway complementaritysince they target different receptors, co-administration may produce synergistic effects without receptor competition

This combination produces superior weight loss compared to single-pathway GLP-1 agents like semaglutide (Ozempic, Wegovy), which activate only the GLP-1 pathway