It sits within the regulatory layer covering laboratory reagents and research chemicals, not the layer governing human therapeutics
GLP-1 is degraded extensively by the endothelial DPP-IV and consequently only 10-15% of secreted GLP-1 enters the systemic circulation in the active form ( In contrast to the high GLP-1 group, DPP-IV inhibition did not significantly alter plasma glucose, insulin levels, insulin resistance and beta cell function indices in the low GLP-1 prediabetes group
Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al
Recently, a significant role for GSTO1 in protein deglutathionylation has been described 11 , and -actin was identified as one of the cellular substrates for GSTO1-catalysed deglutathionylation
In addition, its high molecular weight (57 kDa) prevents renal clearance and prolongs its half-life (133)