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Additional factors such as increased release of adiponectin from adipose tissue, amelioration of insulin resistance in liver and peripheral tissues, and improved circulatory lipid profile all contribute to the reduced risk of ASCVD (267)

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Next, we knocked down cavolin-1 or clathrin in human caECs using a siRNA and observed no effect on cellular internalization of FAM(2836) (Supplemental Figure 6, C and D)

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