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IGF-1 replacement therapy, within physiological ranges, may restore metabolic balance, improving carbohydrate and lipid metabolism while supporting overall metabolic health and nutrient utilization (7)

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On the other hand, the research of Fukuda and co-researchers showed that there was a significant negative correlation between blood ammonia and free carnitine concentrations in epileptic children ( P = 0.003) and this high serum level of ammonia was associated with increased severity of seizures in their series of patients 25

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In male reproductive pathology, ROS generated by mitochondria in asthenozoospermic sperm cause nuclear DNA strand breaks [358] and compromise chromatin condensation integrity through aberrant histone methylation patterns, which directly correlates with diminished sperm quality [351]