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Nevertheless, similar to glutamine synthetase, elevated levels of Mn can reduce MnSOD expression

Figure 1 3.2 Metformin treatment significantly radiosensitises HCT116 and SW837 CRC cells Having demonstrated metformin-mediated inhibition of oxidative phosphorylation in both HCT116 and SW837 cells, the potential of metformin as a radiosensitiser in vitro was investigated