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Slow and gradual dose escalation also helps reduce gastrointestinal side effects and improve tolerability

GLP-1 RAs under development for NASH Semaglutide Semaglutide showed a significant dose-dependent NASH resolution without worsening of fibrosis in a phase 2 randomized controlled trial (RCT) involving patients with NASH and stage 13 fibrosis

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The consequences of these deficiencies show up in ways that many GLP-1 users initially attribute to the medication itself