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This overlap suggests a complex interaction between oral and intestinal microecology, where oral bacteria can colonize the gut, significantly influencing various pathophysiological processes

This receptor interaction creates: Reversible blockade of ion channel opening , preventing sodium ion uptake Reduced frequency of muscle cell excitation and contraction Temporary relaxation of superficial facial muscles Decreased formation of dynamic expression lines In vitro studies using cultured muscle cells demonstrated that 0.025% Syn-AKE reduced muscle contraction frequency by 36% after one minute and 82% after two hours, indicating rapid onset with sustained activity[2]