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a computational approach to identify sets of co-regulated genes associated with treatment outcomes) on bulk RNA-seq data was applied where groups of genes that move in the same direction between conditions are packed into modules

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2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter