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Other components including IgA, enzymes, proteins such as lactoferrin and those with antimicrobial properties including bile acids and AMPs, are also present in these mucosal layers and function collectively to restrict the interaction of luminal contents with the epithelial layer (Singh et al

In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

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PMCID: PMC1863555