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Currently, only three FDA-approved medications exist for treating alcohol use disorder: naltrexone (approved 1994), acamprosate (approved 2004), and disulfiram (approved 1949)

These compounds vary in chemical structure, pharmacokinetics and size, which results in different clinical effects on hyperglycaemia and body weight loss

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In parallel, cholinergic parasympathetic neurons, whose cell bodies reside in the sacral parasympathetic nucleus (S2S4) and project to the pelvic plexus and corpora cavernosa, release acetylcholine