2026, biostimulator pricing came down Sculptra and Radiesse, the two leading collagen biostimulators, saw distributor pricing soften across late 2025
Although natalizumab is believed to be more potent on clinical and MRI outcomes than first-line injectable immunomodulators,Reference Putzki, Yaldizli and Buhler 86 this has never been shown in properly controlled studies, but is substantiated only with large, real world observational data sets.Reference Spelman, Kalincik and Zhang 87 With respect to escalation from either IFN- or GA to natalizumab, retrospective and observational studies have indicated that switching is associated with a significant reduction in clinical and radiological activity.Reference Prosperini, Gianni and Leonardi 88 - Reference Krysko and OConnor 90 A switch from IFN- to fingolimod has also been shown to produce significant reductions in clinical and radiological activity.Reference Khatri, Barkhof and Comi 91 However, no large head-to-head studies or evidence-based criteria exist to guide the choice between fingolimod and natalizumab
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Most events were grade 1 or 2
For severe symptoms such as intense abdominal pain, persistent vomiting, signs of dehydration, or suspected pancreatitis, contact NHS 111 or attend urgent care/A&E as appropriate
