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However, no trials have tested GLP-1RAs as stroke treatments or secondary prevention agents, so the relative contribution of CNS versus systemic mechanisms remains unclear

Prolonged dysregulation can lead to an 'anti-reward' brain state, characterized by reduced sensitivity to natural rewards and heightened vulnerability to compulsive behaviors

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Strong scientific evidence is now implicating oxidative stress in individuals susceptibility to detrimental health outcomes with COVID-19 [1, 2]

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