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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

Markings run from 0 to 30 in increments of 0.5 units

LPS interacts with TLR 4 on immune cells, activating the nuclear factor kappa-light-chain-enhancer of activated B (NF- B) cells signaling pathway (Pea-Durn et al., 2025)

CYTb encodes apocytochrome b of ubiquinol: ferricytochrome c oxidoreductase ND , COX and ATP refer to genes coding for subunits of NADH: ubiquinone oxidoreductase, ferrocytochrome c : oxygen oxidoreductase (cytochrome c oxidase) and F 1 F 0 -ATP synthase, respectively