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This combination therapy results in increased activation of CD8 + T cells and CD86 + dendritic cells in the spleen, leading to elevated levels of pro-inflammatory cytokines [206]

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The SELECT trial established cardiovascular risk reduction as a class effect, leading to expanded indications for these medications ^1

Both fixed- (FEM) and random-effect (REM) models were utilized in the meta-analyses for outcome interpretation depending on between-study heterogeneity which was tested by I 2 index