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Injectable therapies remain the standard for both indications, but patient expectations differ

GLP-1 receptor agonists, such as semaglutide and liraglutide, are primarily used to manage type 2 diabetes and have been shown to aid in weight loss

After years of record losses, Massachusetts largest health insurers appear to have shaken off the shock of the wildly popular but hugely expensive GLP-1 weight loss drugs, with each reporting healthy financial results on Friday for the first quarter this year

The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly

Follow Slow Dose Escalation (4-Week Minimum) Stay at each dose for a full 4 weeks before increasing