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10.1001/jamapsychiatry.2013.4374 129 ErnyD.Hrab De AngelisA

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Levocarnitine was not bound to plasma protein or albumin when tested at any concentration or with any species including the human.9 In a pharmacokinetic study where five normal adult male volunteers received an oral dose of [ 3H-methyl]-L-carnitine following 15 days of a high carnitine diet and additional carnitine supplement, 58 to 65% of the administered radioactive dose was recovered in the urine and feces in 5 to 11 days

We uncover a previously unrecognized human-specific function of -KG that connects energy sensing to tumor cell survival under stress through AMPK translational regulation