soul trial oral semaglutide cardiovascular outcomes 2024 nejm Editorial Fellow Harleen Marwah, MD, summarizes the trial. Visit NEJM.org for the full results. #ACC25 #Cardiology #ClinicalTrials #MedTok #NEJM Cardiovascular risk reduction with once-weekly

Less common but important side effects Some side effects warrant closer attention: Hair loss

Semaglutide enhances insulin secretion in response to meals and slows gastric emptying, which prevents the rapid blood sugar spikes and crashes that cloud cognition

Because it has its own local foot soldiers who can promote the products efficiently and reach the lower-tier markets, which a lot of MNCs have difficulties penetrating. Eli Lilly is also developing Mazdutide in parallel outside of China and is currently in phase 2 clinical trials

Gut microbiota dysbiosis in patients with comorbid chronic constipation and depression may exhibit synergistic effects

The potential harms outweigh the likely small, short-lived benefits