New England Journal of Medicine , 383(15), 1436-1446
We also offer a tablet form that dissolves under the tongue and is taken daily
Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play a major role in determining the physiological profile of insulin release following a meal (2, 3)
The mechanism of action involves slowing gastric emptying, enhancing glucose-dependent insulin secretion, and suppressing inappropriate glucagon secretion
It is worth noting that recent clinical trials (such as STEP-HFpEF) suggest that despite a reduction in lean body mass, patients physical functioning (such as exercise endurance) may still significantly improve, indicating that we need to reassess the clinical balance between muscle mass decline and functional benefits.In clinical practice, the potential risks of GLP-1RAs cannot be ignored, especially in the elderly and those already suffering from sarcopenia