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In the foundational 1996 dose-ranging study in healthy elderly subjects, oral MK-677 increased 24-hour GH concentrations in a dose-dependent manner roughly doubling mean GH at the 25 mg dose and the researchers attributed this to an enhancement of pre-existing pulsatile GH secretion : pulse height and interpulse nadir concentrations rose, while the number of pulses did not change significantly

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Neuropharmacology 167:107742 Tian Z, Clark BL, Menard F (2019) Kainic acid-based agonists of glutamate receptors: SAR analysis and guidelines for analog design