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However, there is also a possibility that some of the effect may be independent of GLP-1, because DPP-4 inhibition still reduced -cell apoptosis in human islets cultured in the presence of exendin 9-39 (99), suggesting that other mediators might be involved, but it was also suggested that an anti-inflammatory action could have played a role (99)
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We found that GPX3 inhibits oxidative stress-related pathways (NFB pathway) and apoptosis-related pathways (Caspase pathway) (Figure 3B), which is consistent with our previous results
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