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The same beneficial effect of KdPT treatment on dextran sodium sulfateinduced colitis was not seen in MC1Rdeficient mice, which suggests a reduced capacity of KdPT to mitigate colitis in the absence of MC1R and a potential role of MC1R in the mechanism of action of KdPT

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vulgatus ), suggesting a potential involvement of the microbiota in the production of this alpha-keto acid from APAP-Cys (Fig