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Li Zhang, [email protected] These authors share first authorship This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Summary: For most people requiring oral supplementation, cyanocobalamin is the most commonly used and effective form of B12, whilst hydroxocobalamin injections are the preferred treatment for confirmed deficiency in UK clinical practice

In a review of studies, researchers found that while vitamin B12 supplementation did not improve depressive symptoms, low vitamin B12 levels were linked to an increased risk of developing depression