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The further addition of GCGR agonism in retatrutide introduces Gs-cAMP signalling in hepatocytes, brown adipose tissue, and the central nervous system cell types with limited or no GLP-1R or GIPR expression expanding the tissue scope of the compound's action profile

Structure Therapeutics' aleniglipron, an oral small-molecule GLP-1 agonist, posted the highest efficacy among oral candidates: 16.3% weight loss at 44 weeks in Phase 2 with only 2% discontinuation due to side effects

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